Triazabicyclodecene → HCID 9893236, compound

Participants

Reaction Steps

4-[4-(4-(2-fluorophenyl)-oxazol-2-yl)-phenoxy]-phenol (142 mg, 0.41 mmol), and 1,5,7-triazabicyclo[4.4.0]dec-5-ene bound to polystyrene crosslinked with 2% DVB (Fluka) (473 mg @ 2.6 meq/g, 1.23 meq) in acetonitrile were shaken for 30 minutes. 5-Bromo-5-(2-methoxy-ethyl)-pyrimidine-2,4,6-trione (163 mg, 0.62 mmol) (from Preparation 3b) was then added and shaking continued for 3 days. The reaction was quenched with 20% acetic acid in methanol and after 15 minutes filtered. The filtrate was concentrated and the crude product chromatographed yielding 145 mg of 5-(2-methoxy-ethyl)-5-{4-[4-(4-(2-fluorophenyl)-oxazol-2-yl)-phenoxy]-phenoxy}-pyrimidine-2,4,6-trione as a white solid. LC-MS (m/z, APCI): 533 [M+H]+.

Provenance & Evidence