Water → HCID 21931109, compound

Participants

Reaction Steps

A mixture of 5-(2-hydroxy-ethyl)-5-{4-[4-(3-(2-fluorophenyl)-[1,2,4]oxadiazol-5-yl)-phenoxy]-phenoxy}-pyrimidine-2,4,6-trione (518 mg, 1.0 mmol), sodium periodate (875 mg, 4.1 mmol), ruthenium trichloride hydrate (7 mg, 0.025 mmol), water (3 mL), acetonitrile (2 mL), and ethyl acetate (2 mL) was stirred vigorously for 4 hours. The mixture was filtered through diatomaceous earth which was then rinsed with ethyl acetate. The filtrate was washed with 10% sodium dithionite solution and brine and then dried over sodium sulfate. Filtration and concentration yielded 418 mg of the title compound as a white solid. LC-MS (m/z, APCI): 533 [M+H]+.

Provenance & Evidence