HCID 21931120, compound → HCID 10311686, compound

HRID 1243968Notes

Reaction equation

HRID 1243968 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[CH:11][C:10]([C:13]3[CH:26]=[CH:25][C:16]([O:17][C:18]4[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=4)=[CH:15][CH:14]=3)=[N:9]2)=[CH:4][CH:3]=1.Br[C:28]1([CH2:37][CH2:38][O:39][CH3:40])[C:33](=[O:34])[NH:32][C:31](=[O:35])[NH:30][C:29]1=[O:36]>>[CH3:40][O:39][CH2:38][CH2:37][C:28]1([O:24][C:21]2[CH:22]=[CH:23][C:18]([O:17][C:16]3[CH:25]=[CH:26][C:13]([C:10]4[CH:11]=[CH:12][N:8]([C:5]5[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=5)[N:9]=4)=[CH:14][CH:15]=3)=[CH:19][CH:20]=2)[C:29](=[O:36])[NH:30][C:31](=[O:35])[NH:32][C:33]1=[O:34]

Participants

3

Reactant 2

HCID 21931120HCID 21931120, compoundHCID 219311515-Bromo-5-(2-methoxyethyl)pyrimidine-2,4,6(1H,3H,5H)-trione

Product 1

HCID 10311686HCID 10311686, compound

Procedure

By the same procedure as Example 1, Part C, 4-{4-[1-(4-Fluoro-phenyl)-1H-pyrazol-3-yl]-phenoxy}-phenol and 5-bromo-5-(2-methoxy-ethyl)-pyrimidine-2,4,6-trione (from Preparation 3B) were converted to the title compound. MS m/z: ESI+531.2 (M+H)+.

Sources & evidence

ORD record
ord-104c58621bf94c2b98f696ec76724cb7
Source dataset
uspto-grants-2006_10
Patent number
US07119201B2

Reaction notes

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