HCID 21931026, compound → HCID 21931017, compound

HRID 1243972Notes

Reaction equation

HRID 1243972 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][C:5]1([O:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]4[NH:32][N:31]=[C:30]([C:33]5[CH:38]=[CH:37][CH:36]=[C:35]([F:39])[CH:34]=5)[CH:29]=4)=[CH:24][CH:23]=3)=[CH:17][CH:16]=2)[C:10](=[O:11])[NH:9][C:8](=[O:12])[NH:7][C:6]1=[O:13].Br[C:41]1(CCOCC)C(=O)NC(=O)NC1=O>>[CH2:1]([O:2][CH2:3][CH2:4][C:5]1([O:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]3[CH:23]=[CH:24][C:25]([C:28]4[NH:32][N:31]=[C:30]([C:33]5[CH:38]=[CH:37][CH:36]=[C:35]([F:39])[CH:34]=5)[CH:29]=4)=[CH:26][CH:27]=3)=[CH:17][CH:16]=2)[C:6](=[O:13])[NH:7][C:8](=[O:12])[NH:9][C:10]1=[O:11])[CH3:41]

Participants

3

Reactant 2

HCID 21931026HCID 21931026, compoundHCID 219311235-Bromo-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione

Product 1

HCID 21931017HCID 21931017, compound

Procedure

By the same procedure as Example 1, Part C, 4-{4-[1-(3-fluorophenyl)-1H-pyrazol-3-yl]-phenoxy}phenol (from Example 71, Part C) and 5-bromo-5-(2-ethoxyethyl)-pyrimidine-2,4,6-trione (from Preparation 3B) were converted to the title compound. MS m/z: ESI+ 545.1 (M+H)+, ESI− 543.3 (M−H)−.

Sources & evidence

ORD record
ord-9531c3517cb943fab8e605055c5a7382
Source dataset
uspto-grants-2006_10
Patent number
US07119201B2

Reaction notes

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