HCID 21931030, compound → HCID 21931020, compound

HRID 1243975Notes

Reaction equation

HRID 1243975 reaction equation
[C:1]1([CH3:26])[CH:6]=[CH:5][C:4]([N:7]2[CH:11]=[CH:10][C:9]([C:12]3[CH:25]=[CH:24][C:15]([O:16][C:17]4[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=4)=[CH:14][CH:13]=3)=[N:8]2)=[CH:3][CH:2]=1.Br[C:28]1([CH2:37][CH2:38][O:39][CH2:40]C)[C:33](=[O:34])[NH:32][C:31](=[O:35])[NH:30][C:29]1=[O:36]>>[CH3:40][O:39][CH2:38][CH2:37][C:28]1([O:23][C:20]2[CH:21]=[CH:22][C:17]([O:16][C:15]3[CH:24]=[CH:25][C:12]([C:9]4[CH:10]=[CH:11][N:7]([C:4]5[CH:3]=[CH:2][C:1]([CH3:26])=[CH:6][CH:5]=5)[N:8]=4)=[CH:13][CH:14]=3)=[CH:18][CH:19]=2)[C:29](=[O:36])[NH:30][C:31](=[O:35])[NH:32][C:33]1=[O:34]

Participants

3

Reactant 2

HCID 21931030HCID 21931030, compoundHCID 219311235-Bromo-5-(2-ethoxy-ethyl)-pyrimidine-2,4,6-trione

Product 1

HCID 21931020HCID 21931020, compound

Procedure

By the same procedure as Example 1, Part C, 4-[4-(1-p-Tolyl-1H-pyrazol-3-yl)-phenoxy]-phenol and 5-bromo-5-(2-methoxyethyl)-pyrimidine-2,4,6-trione (from Preparation 3B) were converted to the title compound. MS m/z: ESI+ 527.2 (M+H)+, ESI− 525.4 (M−H)−.

Sources & evidence

ORD record
ord-9c280738e7714199a8fa9788678019a7
Source dataset
uspto-grants-2006_10
Patent number
US07119201B2

Reaction notes

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