反应详情

[2-({3-[(6-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-ylmethyl)-amino]-(2S,3S)-2-phenyl-piperidine-1-carbothioyl}-amino)-ethyl]-carbamic acid tert-butyl ester (800 mg, 1.38 mmol) was stirred in a mixture of 30 mL methylene chloride and 10 mL trifluoroacetic acid at room temperature for 4 hours. The solvent was removed and the residue was partitioned between ethyl acetate and satd. K2CO3. The organics were separated, dried over MgSO4, filtered, and concentrated to give 3-[(6-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-ylmethyl)-amino]-2-phenyl-piperidine-1-carbothioic acid (2-amino-ethyl)-amide. Rf=0.18 (90:10:1 methylene chloride/methanol/satd. aq. NH4OH).

1. customThe solvent was removed
2. customthe residue was partitioned between ethyl acetate and satd
3. customThe organics were separated
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated