HCID 9964644, compound → HCID 21931761, compound

HRID 1244071Notes

Reaction equation

HRID 1244071 reaction equation
[CH2:1]([CH:4]1[NH:9][CH:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:7]([NH2:16])[CH2:6][CH2:5]1)[CH2:2][CH3:3].C([C@@H]1N[C@@H](C2C=CC=CC=2)[C@@H](N)CC1)CC.C([C@H]1N[C@H](C2C=CC=CC=2)[C@H](N)CC1)CC.[CH3:49][O:50][C:51]1[CH:60]=[C:59]2[C:54]([N:55]([CH3:63])[C:56](=[O:62])[CH:57]3[CH2:61][CH:58]32)=[CH:53][C:52]=1[CH:64]=O>>[CH3:49][O:50][C:51]1[CH:60]=[C:59]2[C:54]([N:55]([CH3:63])[C:56](=[O:62])[CH:57]3[CH2:61][CH:58]32)=[CH:53][C:52]=1[CH2:64][NH:16][CH:7]1[CH2:6][CH2:5][CH:4]([CH2:1][CH2:2][CH3:3])[NH:9][CH:8]1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

5

Reactant 4

HCID 9964644HCID 9964644, compoundHCID 21931707HCID 21931707, compoundHCID 69654472(2R,3R,6R)-6-propyl-2-phenyl-piperidin-3-ylamineHCID 69654610(2S,3S,6S)-6-propyl-2-phenyl-piperidin-3-ylamine

Product 1

HCID 21931761HCID 21931761, compound

Procedure

By a procedure similar to the previous examples 9 and 9A: prepared through the reaction of 6-propyl-2-phenyl-piperidin-3-ylamine [or (2S,3S,6S)-6-propyl-2-phenyl-piperidin-3-ylamine or (2R,3R,6R)-6-propyl-2-phenyl-piperidin-3-ylamine] with 6-Methoxy-3-methyl-2-oxo-1a,2,3,7b-tetrahydro-1H-3-aza-cyclopropa[a]naphthalene-5-carbaldehyde [or (1S,1aR)-6-Methoxy-3-methyl-2-oxo-1a,2,3,7b-tetrahydro-1H-3-aza-cyclopropa[a]naphthalene-5-carbaldehyde or (1R,1aS)-6-Methoxy-3-methyl-2-oxo-1a,2,3,7b-tetrahydro-1H-3-aza-cyclopropa[a]naphthalene-5-carbaldehyde].

Sources & evidence

ORD record
ord-6655a6118a76443eb24a703afacdd798
Source dataset
uspto-grants-2006_10
Patent number
US07119207B2

Reaction notes

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