6-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline-7-carbaldehyde → HCID 21931655, compound

HRID 1244072Notes

Reaction equation

HRID 1244072 reaction equation
[CH2:1]([CH:4]1[NH:9][CH:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:7]([NH2:16])[CH2:6][CH2:5]1)[CH2:2][CH3:3].C([C@@H]1N[C@@H](C2C=CC=CC=2)[C@@H](N)CC1)CC.C([C@H]1N[C@H](C2C=CC=CC=2)[C@H](N)CC1)CC.[CH3:49][O:50][C:51]1[CH:52]=[C:53]2[C:58](=[CH:59][C:60]=1[CH:61]=O)[N:57]([CH3:63])[C:56](=[O:64])[CH2:55][CH2:54]2>>[CH3:49][O:50][C:51]1[CH:52]=[C:53]2[C:58](=[CH:59][C:60]=1[CH2:61][NH:16][CH:7]1[CH2:6][CH2:5][CH:4]([CH2:1][CH2:2][CH3:3])[NH:9][CH:8]1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[N:57]([CH3:63])[C:56](=[O:64])[CH2:55][CH2:54]2

Participants

5

Reactant 4

HCID 101251786-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline-7-carbaldehydeHCID 21931707HCID 21931707, compoundHCID 69654472(2R,3R,6R)-6-propyl-2-phenyl-piperidin-3-ylamineHCID 69654610(2S,3S,6S)-6-propyl-2-phenyl-piperidin-3-ylamine

Product 1

HCID 21931655HCID 21931655, compound

Procedure

By a procedure similar to the previous examples 9 and 9A: prepared through the reaction of 6-propyl-2-phenyl-piperidin-3-ylamine [or (2S,3S,6S)-6-propyl-2-phenyl-piperidin-3-ylamine or (2R,3R,6R)-6-propyl-2-phenyl-piperidin-3-ylamine] with 6-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydro-quinoline-7-carbaldehyde.

Sources & evidence

ORD record
ord-2c210d2b377647b5a2b6273cd27a321c
Source dataset
uspto-grants-2006_10
Patent number
US07119207B2

Reaction notes

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