6-Methyl-2-phenylpiperidin-3-amine → 6-Methoxy-1-methyl-7-[(6-methyl-2-phenyl-piperidin-3-ylamino)-methyl]-3,4-dihydro-1H-quinolin-2-one

HRID 1244074Notes

Reaction equation

HRID 1244074 reaction equation
[CH3:1][CH:2]1[NH:7][CH:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:5]([NH2:14])[CH2:4][CH2:3]1.C[C@@H]1N[C@@H](C2C=CC=CC=2)[C@@H](N)CC1.C[C@H]1N[C@H](C2C=CC=CC=2)[C@H](N)CC1.[CH3:43][O:44][C:45]1[CH:46]=[C:47]2[C:52](=[CH:53][C:54]=1[CH:55]=O)[N:51]([CH3:57])[C:50](=[O:58])[CH2:49][CH2:48]2>>[CH3:43][O:44][C:45]1[CH:46]=[C:47]2[C:52](=[CH:53][C:54]=1[CH2:55][NH:14][CH:5]1[CH2:4][CH2:3][CH:2]([CH3:1])[NH:7][CH:6]1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[N:51]([CH3:57])[C:50](=[O:58])[CH2:49][CH2:48]2

Participants

5

Reactant 4

HCID 98775926-Methyl-2-phenylpiperidin-3-amineHCID 101251786-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydroquinoline-7-carbaldehydeHCID 21069315(2S,3S,6S)-6-methyl-2-phenyl-piperidin-3-ylamineHCID 69654587HCID 69654587, compound

Product 1

HCID 101352126-Methoxy-1-methyl-7-[(6-methyl-2-phenyl-piperidin-3-ylamino)-methyl]-3,4-dihydro-1H-quinolin-2-one

Procedure

By a procedure similar to the previous examples 9 and 9A: prepared through the reaction of 6-methyl-2-phenyl-piperidin-3-ylamine [or (2S,3S,6S)-6-methyl-2-phenyl-piperidin-3-ylamine or (2R,3R,6R)-6-methyl-2-phenyl-piperidin-3-ylamine] with 6-Methoxy-1-methyl-2-oxo-1,2,3,4-tetrahydro-quinoline-7-carbaldehyde.

Sources & evidence

ORD record
ord-bd4093f4f1a44449a956cd501406e238
Source dataset
uspto-grants-2006_10
Patent number
US07119207B2

Reaction notes

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