N-Bromosuccinamide → HCID 54689823, compound

Participants

Reaction Steps

To a stirred solution of 4-hydroxy-3-[4-(5-hydroxy-pent-1-ynyl)-phenyl]-6-oxo-6,7-dihydro-thieno[2,3-b]pyridine-5-carbonitrile (35 mg, 0.1 mmol) in acetic acid (1 mL) was added N-bromosuccinamide (18 mg, 0.1 mmol) in a single portion at room temperature, and stirred at rt overnight. The reaction mixture was concentrated and purified by reverse phase HPLC to afford the titled compound. MS (ESI) m/e 428 (M−H)+; 1H NMR (300 MHz, DMSO-d6): δ 1.68–1.75 (m, 2H), 3.51–3.57 (m, 2H), 4.54 (t, J=5.26 Hz, 2H), 7.19 (d, J=8.48 Hz, 2H), 7.31 (d, J=8.48 Hz, 2H).

Provenance & Evidence