Diethyl Ether → HCID 69607348, compound

Participants

Reaction Steps

An ambient mixture of 2-(2-cyano-acetylamino)-4-(4-aminophenyl)-5-chloro-thiophene-3-carboxylic acid ethyl ester (365 mg, 1.00 mmol), NaHCO3 (210 mg, 2.50 mmol), and allyl bromide (0.173 mL, 2.00 mmol) in DMF (3.5 mL) was stirred for 18 h. The reaction was then diluted with H2O (5 mL) and Et2O (5 mL). The layers were separated, and the aqueous was extracted with additional Et2O (2×5 mL). The combined organic layers were dried with anhydrous Na2SO4, filtered, and concentrated under reduced pressure to an oil that was used without further purification. MS (ESI) m/e 442 (M−H)−.

Provenance & Evidence