Hydrochloric Acid → HCID 54689858, compound

Participants

Reaction Steps

To a suspension of NaH (275 mg, 6.87 mmol) in THF (50 mL) was added 4-(4-benzyloxy-3,5-dibromo-phenyl)-2-(2-cyano-acetylamino)-thiophene-3-carboxylic acid ethyl ester from Example 36D (1.8 g, 3.12 mmol) in THF (50 mL). The reaction stirred at room temperature for 18 h. It was acidified with 1M HCl and concentrated in vacuo. The resulting orange solid was taken up in H2O and filtered, rinsing with H2O (2×20 mL) and CH2Cl2 (3×20 mL). The titled compound was isolated as a yellow solid (940 mg, 1.76 mmol, 56% yield).

Provenance & Evidence