HCID 69607367, compound → HCID 54689937, compound

HRID 1244163Notes

Reaction equation

HRID 1244163 reaction equation
C(O[C:4]([C:6]1[C:10]([C:11]#[C:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:9][S:8][C:7]=1[NH:19][C:20](=[O:24])[CH2:21][C:22]#[N:23])=[O:5])C.C(OC(C1C(C=CC2C=CC=CC=2)=CSC=1NC(=O)CC#N)=O)C>>[OH:5][C:4]1[C:6]2[C:10]([C:11]#[C:12][C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)=[CH:9][S:8][C:7]=2[NH:19][C:20](=[O:24])[C:21]=1[C:22]#[N:23]

Participants

3

Reactant 2

HCID 69607367HCID 69607367, compoundHCID 69607389HCID 69607389, compound

Product 1

HCID 54689937HCID 54689937, compoundYield 5.8%

Procedure

Example 241 was prepared using the same procedure as described for Example 240 substituting 2-(2-cyano-acetylamino)-4-phenylethynyl-thiophene-3-carboxylic acid ethyl ester (0.087 g, 0.256 mmol) for 2-(2-Cyano-acetylamino)-4-styryl-thiophene-3-carboxylic acid ethyl ester in Example 240 to give the title compound (0.0043 g, 5.8%). MS m/e (CI) 292.8 (M+H)+314.8 (M+Na); 1H NMR (300 MHz, MeOH-d4) δ ppm 7.09 (s, 1H), 7.33 (m, 3H), 7.58 (m, 2H).

Workup

  1. customExample 241 was prepared

Sources & evidence

ORD record
ord-1b572de635be461ea9bdd2f61a9550f1
Source dataset
uspto-grants-2006_10
Patent number
US07119205B2

Reaction notes

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