HCID 54689878, compound → HCID 54689870, compound

Participants

Reaction Steps

To a suspension of Pd (BaSO4) (15 mg) in toluene (2 mL) and methanol (1 mL), was added 4-hydroxy-3-[4-(5-hydroxy-pent-1-ynyl)-phenyl]-6-oxo-6,7-dihydro-thieno[2,3-b]pyridine-5-carbonitrile (50 mg) in a single portion. The reaction was purged with hydrogen, and stirred under atmosphere hydrogen at rt for 24 h. The mixture was filtered through celite, and rinsed with methanol. The filtrate was concentrated and purified via reverse phase HPLC to afford the titled compound. MS (ESI) m/e 353 (M−H)+; 1H NMR (500 MHz, DMSO-d6): δ 1.31–1.47 (m, 4H), 1.55–1.61 (m, 2H), 1.94 (t, J=7.64 Hz, 2H), 2.58 (t, J=7.64 Hz, 2H), 6.91 (s, 1H), 7.15 (d, J=8.11 Hz, 2H), 7.31 (d, J=8.11 Hz, 2H).

Provenance & Evidence