HCID 12994715, compound → HCID 12994716, compound

HRID 1244178Notes

Reaction equation

HRID 1244178 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[Cl:16])=[CH:6][C:5]=1[OH:17])([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[Cl:16])=[CH:6][C:5]=1[OH:17]

Participants

4

Reactant 1

HCID 12994715HCID 12994715, compound

Product 1

HCID 12994716HCID 12994716, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

9.9 g (40 mmol) of 4-nitro-2′[1,1′-biphenyl]-3-ol from step A was dissolved in 120 mL of ethanol and hydrogenated in the presence of 0.8 g of a palladium-activated carbon catalyst (10%) at 25° C. After the required amount of hydrogen had been absorbed, the catalyst was filtered off, and the solvent was distilled off in a rotary evaporator. This gave 8.1 g of 4-amino-2′-chloro[1,1′-biphenyl]-3-ol.

Workup

  1. customAfter the required amount of hydrogen had been absorbed
  2. filtrationthe catalyst was filtered off
  3. distillationthe solvent was distilled off in a rotary evaporator

Sources & evidence

ORD record
ord-eeab12dc2d8a4a3b8008a6c122e51eeb
Source dataset
uspto-grants-2006_10
Patent number
US07122061B2

Reaction notes

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