Diglycolamine → HCID 57357491, compound

Participants

Reaction Steps

A solution of di-tert-butylcarbonate (10.27 g, 47.2 mmol) in chloroform (40 mL) was added to a solution of 2-(2-aminoethoxy)-ethanol (5.0 g, 47.62 mmol) in chloroform (40 mL) and the mixture was stirred at room temperature for 1.5 hrs. The solution was washed with water (30 mL), the organic layer dried (MgSO4), and concentrated in vacuo to give 2-(2-Boc-aminoethoxy)-ethanol (9.6 g, 99%). 1H NMR (300 MHz, CDCl3) δ 5.43 (s, 1H), 3.43 (s, 1H), 3.56 (mn, 4H), 3.73 (t, 2H, J=5.4 Hz), 3.32 (m, 2H), 1.45(s, 9H); 13C NMR (67.8 MHz, CDCl3) δ 156.06, 79.06, 77.18, 72.14, 70.08, 61.31, 40.21, 28.21.

Provenance & Evidence