2-(Ethylamino)ethanol → 4-Ethoxy-N-ethyl-N-(2-hydroxyethyl)-3-(5,7-dimethyl-4-oxo-3,4-dihydro-imidazo[5,1-f]-[1,2,4]triazin-2-yl)benzenesulphonamide

HRID 1244224Notes

Reaction equation

HRID 1244224 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][C:5]=1[C:14]1[NH:19][C:18](=[O:20])[C:17]2=[C:21]([CH3:25])[N:22]=[C:23]([CH3:24])[N:16]2[N:15]=1)[CH3:2].[CH2:26]([NH:28][CH2:29][CH2:30][OH:31])[CH3:27]>>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10]([N:28]([CH2:26][CH3:27])[CH2:29][CH2:30][OH:31])(=[O:12])=[O:11])=[CH:6][C:5]=1[C:14]1[NH:19][C:18](=[O:20])[C:17]2=[C:21]([CH3:25])[N:22]=[C:23]([CH3:24])[N:16]2[N:15]=1)[CH3:2]

Participants

3

Reactant 2

HCID 80722-(Ethylamino)ethanolHCID 1358567774-Ethoxy-3-(5,7-dimethyl-4-oxo-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)-benzenesulphonyl chloride

Product 1

HCID 1355440954-Ethoxy-N-ethyl-N-(2-hydroxyethyl)-3-(5,7-dimethyl-4-oxo-3,4-dihydro-imidazo[5,1-f]-[1,2,4]triazin-2-yl)benzenesulphonamide

Procedure

By the same method, starting with 100 mg (0.261 mmol) of 4-ethoxy-3-(5,7-dimethyl-4-oxo-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)-benzenesulphonyl chloride and 70 mg (0.784 mmol) of 2-(ethylamino)-ethanol, 23 mg (20.1% of theory) of 4-ethoxy-N-ethyl-N-(2-hydroxyethyl)-3-(5,7-dimethyl-4-oxo-3,4-dihydroimindazo-[5,1-f][1,2,4]triazin-2-yl)-benzene-sulphonamide are obtained.

Workup

  1. customare obtained

Sources & evidence

ORD record
ord-175131b6b171421e9ac50a9c896adfd1
Source dataset
uspto-grants-2006_10
Patent number
US07122540B2

Reaction notes

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