Potassium Carbonate → HCID 10337487, compound

Participants

Reaction Steps

Excess K2CO3 is added to a stirred solution of 3-chloromethyl-4,6-diethoxy-pyridazine (70 mg, 0.32 mmol) and 2-fluoro-6-(1H-imidazol-2-yl)-pyridine (52 mg, 0.32 mmol) in DMF (6 mL). The mixture is stirred at room temperature overnight. The solvent is removed in vacuo and water (5 mL) and EtOAc (8 mL) are added. The layers are separated and the aqueous layer is extracted with EtOAc (8 mL). The combined extracts is washed with brine (10 mL) and dried (Na2SO4) and evaporated. Preparative TLC purification of the residue (5% MeOH in CH2Cl2) provides the title compound as a light yellow oil. H1 NMR δ (CDCl3) 8.07–8.10 (m, 1H), 7.82 (q, 1H, J=7.8 Hz), 7.14 (s, 2H), 6.80–6.84 (m, 1H), 6.22 (s, 1H), 6.11 (s, 2H), 4.50 (q, 2H, J=7.2 Hz), 3.95 (q, 2H, J=7.2 Hz), 1.39 (t, 3H, J=7.2 Hz), 1.18 (t, 3H, J=7.2 Hz).

Provenance & Evidence