Water → HCID 11723027, compound

HRID 1244266Notes

Reaction equation

HRID 1244266 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5]([CH2:8][N:9]2[CH:13]=[CH:12][N:11]=[C:10]2[C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[CH:15]=2)=[C:4]([CH2:21][CH3:22])[CH:3]=1.[CH3:23][O-:24].[Na+].O>CO>[CH2:21]([C:4]1[CH:3]=[C:2]([O:24][CH3:23])[N:7]=[N:6][C:5]=1[CH2:8][N:9]1[CH:13]=[CH:12][N:11]=[C:10]1[C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([F:20])[CH:15]=1)[CH3:22]

Participants

5

Reactant 3

HCID 962WaterHCID 9995922HCID 9995922, compoundHCID 10942334Sodium Methoxide

Product 1

HCID 11723027HCID 11723027, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 6-chloro-4-ethyl-3-[2-(3-fluoro-phenyl)-imidazol-1-ylmethyl]-pyridazine (73.3 mg, 0.23 mmol) and sodium methoxide (40 mg, 0.74 mmol) in methanol (5 mL) is heated under N2 for 5 hours. After cooling, water (10 mL) is added, followed by extraction with ethyl acetate (3×30 mL). The solvent is removed in vacuo and PTLC separation gives the title compound. LC-MS (M+1) 313.1 (retention time: 0.99 min).

Workup

  1. temperatureAfter cooling
  2. extractionfollowed by extraction with ethyl acetate (3×30 mL)
  3. customThe solvent is removed in vacuo and PTLC separation

Sources & evidence

ORD record
ord-16c4b174fabe40e2a841a1cfd3aa4ef5
Source dataset
uspto-grants-2006_10
Patent number
US07122546B2

Reaction notes

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