反应详情

In accordance with scheme 2,4-methoxy-7-morpholin-4-yl-benzothiazole-2-carboxylic acid (for R1=morpholinyl, XII) and CDI (1,1′-carbonyl-diimidazole) was stirred at room temperature for about 1.5 hours. Then, for example, 2-amino-1-(2-thienyl)ethanone hydrochloride (for R3=thienyl) and triethylamine were added and stirring are continued over night at room temperature. Then a mixture of the obtained 4-methoxy-7-morpholin-4-yl-benzothiazole-2-carboxylic acid (2-oxo-2-thiophen-2-yl-ethyl)-amide (III) and ammonium triflouroacetate was melted at about 165° C. for 60 minutes to obtain 4-methoxy-7-morpholin-4-yl-2-(4-thiophen-2-yl-1H-imidazol-2-yl)-benzothiazole (Ia1 for R1=morpholinyl and R3=thienyl).

1. waitare continued over night at room temperature
2. customfor 60 minutes