反应详情

0.05 g of 2-(1H-Benzoimidazol-2-yl)-4-methoxy-7-morpholin-4-yl-benzothiazole (0.14 mmol) were dissolved in dry DMF (2.0 ml) and treated with 0.005 g NaH (65% in oil, 0.14 mmol) at 0° C. After stirring at ambient temperature for 1 h, 25 μl MeI (0.4 mmol) was added and the reaction mixture was stirred for 16 h. The suspension was filtered and the residue on the filter dried in vacuo. One obtained 0.042 g of 4-methoxy-2-(1-methyl-1H-benzoimidazol-2-yl)-7-morpholin-4-yl-benzothiazole (81%) as a yellow solid; M.p.: 283–285° C.

1. stirringthe reaction mixture was stirred for 16 h
2. filtrationThe suspension was filtered
3. customthe residue on the filter dried in vacuo