Pyrrolidine → HCID 21919250, compound

Participants

Reaction Conditions

Reaction Steps

0.1 g 5-Chloro-3-methoxymethyl-2-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-3H-imidazo[4,5-b]pyridine (0.22 mmol) was dissolved in pyrrolidine (5 ml) in an autoclave and heated to 130° C. for 16 h. The residue was triturated in water whereupon a precipitate formed, which was isolated and dried in vacuo. 0.08 g 3-methoxymethyl-2-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-5-pyrrolidin-4-yl-3H-imidazo[4,5-b]pyridine (74%) were obtained as a yellow solid; M.p.: 120–130° C.

Provenance & Evidence