N-methyl-2-pyrrolidone → HCID 21919247, compound

Participants

Reaction Conditions

Reaction Steps

0.05 g 5-Chloro-2-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-3H-imidazo[4,5-b]pyridine (0.11 mmol), 0.034 g 4-hydroxypiperidine (0.34 mmol), 1 mg DMAP and 0.4 ml Hünigs base (2.2 mmol) were dissolved in NMP (1 ml). After stirring for 72 h at 120° C., the reaction mixture was concentrated and the residue taken up in water. A precipitation formed, which was filtered and dried in vacuo to yield 0.04 g 1-[3-methoxymethyl-2-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-3H-imidazo[4,5-b]pyridin-5-yl]-piperidin-4-ol (70%) as a light brown solid; M.p.: 120–130° C.

Provenance & Evidence