HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-Methoxy-7-morpholin-4-yl-benzothiazole-2-carboxylic acid (2-oxo-2-phenyl-ethyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | Ethanone, 2-amino-1-phenyl-, hydrochloride (1:1) | HCID 2723597 | — |
| Reactant | 4-Methoxy-7-morpholin-4-yl-benzothiazole-2-carboxylic acid | HCID 21919216 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Methoxy-7-morpholin-4-yl-benzothiazole-2-carboxylic acid (2-oxo-2-phenyl-ethyl)-amide | HCID 21137066 | 64.4% |
Reaction Steps
0.20 g 4-Methoxy-7-morpholin-4-yl-benzothiazole-2-carboxylic acid and 0.125 g 1,1′-carbonyl-diimidazole in 1 ml DMF were stirred at room temperature for 1 hour. 0.13 g 2-aminoacetophenone hydrochloride and 0.08 g triethylamine were added and stirring was continued for two days at room temperature. 200 ml water was added and the mixture was extracted with ethylacetate. Chromatography on silicagel with ethylacetate/hexane 4:6 yielded 0.18 g (64%) 4-methoxy-7-morpholin-4-yl-benzothiazole-2-carboxylic acid (2-oxo-2-phenyl-ethyl)-amide as a yellow solid; M.p.: 197–200° C.; MS (ISP): m/e=412 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07122545B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-b1b67c0c831d4f00aa761ad6fb77f8f8 |
| Source note | uspto-grants-2006_10 |