反应详情

A mixture of 0.18 g 4-methoxy-7-morpholin-4-yl-benzothiazole-2-carboxylic acid (2-oxo-2-phenyl-ethyl)-amide and 0.57 g ammonium triflouroacetate was melted at 165° C. for 40 minutes and, after cooling to room temperature, suspended in water. Extraction with dichloromethane and chromatography on silicagel with ethylacetate/hexane 1:2 gave 0.07 g (41%) 4-methoxy-7-morpholin-4-yl-2-(4-phenyl-1H-imidazol-2-yl)-benzothiazole as yellow solid; M.p.: 226–233° C.; MS (ISP): m/e=393 (M+H+).

1. customfor 40 minutes
2. extractionExtraction with dichloromethane and chromatography on silicagel with ethylacetate/hexane 1:2