反应详情

A mixture of 0.19 g 4-methoxy-7-morpholin-4-yl-benzothiazole-2-carboxylic acid [2-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-2-oxo-ethyl]-amide and 0.54 g ammonium triflouroacetate was melted at 175° C. for 45 minutes and, after cooling to room temperature, suspended in water. Extraction with dichloromethane and chromatography on silicagel with ethylacetate/hexane 6:4 gave 0.13 g (71%) 2-[4-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-1H-imidazol-2-yl]-4-methoxy-7-morpholin-4-yl-benzothiazole as yellow solid; M.p.: 235–237° C.; MS (ISP): m/e=451 (M+H+).

1. customfor 45 minutes
2. extractionExtraction with dichloromethane and chromatography on silicagel with ethylacetate/hexane 6:4