反应详情

A mixture of 0.15 g 4-methoxy-7-morpholin-4-yl-benzothiazole-2-carboxylic acid (2-benzo[b]thiophen-3-yl-2-oxo-ethyl)-amide and 0.43 g ammonium triflouroacetate was melted at 210° C. for 30 minutes and, after cooling to room temperature, suspended in water. Extraction with dichloromethane and chromatography on silicagel with ethylacetate/hexane 1:1 gave 0.10 g (69%) 2-(5-benzo[b]thiophen-3-yl-1H-imidazol-2-yl)-4-methoxy-7-morpholin-4-yl-benzothiazole as yellow solid; M.p.: 161–162° C.; MS (ISP): m/e=449 (M+H+).

1. customfor 30 minutes
2. extractionExtraction with dichloromethane and chromatography on silicagel with ethylacetate/hexane 1:1