反应详情

A mixture of 0.10 g 4-methoxy-7-morpholin-4-yl-benzothiazole-2-carboxylic acid (2-oxo-2-thiophen-2-yl-ethyl)-amide and 0.32 g ammonium triflouroacetate was melted at 165° C. for 60 minutes and, after cooling to room temperature, suspended in water. Extraction with dichloromethane and chromatography on silicagel with ethylacetate/hexane 1:1 gave 0.02 g (25%) 4-methoxy-7-morpholin-4-yl-2-(4-thiophen-2-yl-1H-imidazol-2-yl)-benzothiazole as yellow solid; MS (ISP): m/e=399 (M+H+).

1. customfor 60 minutes
2. extractionExtraction with dichloromethane and chromatography on silicagel with ethylacetate/hexane 1:1