HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium trifluoroacetate → 4-methoxy-7-morpholin-4-yl-2-(4-thiophen-3-yl-1H-imidazol-2-yl)-benzothiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium trifluoroacetate | HCID 2724268 | — |
| Reactant | 4-Methoxy-7-morpholin-4-yl-benzothiazole-2-carboxylic acid (2-oxo-2-thiophen-3-yl-ethyl)-amide | HCID 21137057 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-methoxy-7-morpholin-4-yl-2-(4-thiophen-3-yl-1H-imidazol-2-yl)-benzothiazole | HCID 178492013 | 62.9% |
Reaction Steps
A mixture of 0.10 g 4-methoxy-7-morpholin-4-yl-benzothiazole-2-carboxylic acid (2-oxo-2-thiophen-3-yl-ethyl)-amide and 0.32 g ammonium triflouroacetate was melted at 170° C. for 50 minutes and, after cooling to room temperature, suspended in water. Extraction with dichloromethane and chromatography on silicagel with ethylacetate/hexane 1:1 gave 0.06 g (59%) 4-methoxy-7-morpholin-4-yl-2-(4-thiophen-3-yl-1H-imidazol-2-yl)-benzothiazole as yellow solid; MS (ISP): m/e=399 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07122545B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-1ae9d2c5cefa4a5fa8a843cfc042200e |
| Source note | uspto-grants-2006_10 |