反应详情

A mixture of 0.16 g 4-methoxy-7-morpholin-4-yl-benzothiazole-2-carboxylic acid [2-(3-methyl-benzo[b]thiophen-2-yl)-2-oxo-ethyl]-amide and 0.44 g ammonium triflouroacetate was melted at 180° C. for 45 minutes and, after cooling to room temperature, suspended in water. Extraction with dichloromethane and chromatography on silicagel with ethylacetate/hexane 1:1 gave 0.08 g (51%) 4-methoxy-2-[5-(3-methyl-benzo[b]thiophen-2-yl)-1H-imidazol-2-yl]-7-morpholin-4-yl-benzothiazole as yellow solid; M.p.: 213–215° C.; MS (ISP): m/e=463 (M+H+).

1. customfor 45 minutes
2. extractionExtraction with dichloromethane and chromatography on silicagel with ethylacetate/hexane 1:1