Triethylamine → HCID 86595005, compound

Participants

Reaction Steps

0.41 g 4-Methoxy-7-morpholin-4-yl-benzothiazole-2-carboxylic acid and 0.14 g 1,1′-carbonyl-diimidazole in 11 ml DMF were stirred at room temperature for 16 hours. 0.16 g 1-amino-3-thiophen-2-yl-propan-2-one hydrochloride and 0.23 ml triethylamine were added and stirring was continued for two days at room temperature. Water was added and the mixture was extracted with ethylacetate. Chromatography on silicagel with ethylacetate/hexane 3:7–7:3 to yielded 0.06 g (18%) 4-methoxy-7-morpholin-4-yl-benzothiazole-2-carboxylic acid (2-oxo-3-thiophen-2-yl-propyl)-amide as a yellow solid; MS (ISP): m/e=432 (M+H+).

Provenance & Evidence