Triethylamine → 4-Methoxy-7-morpholin-4-yl-benzothiazole-2-carboxylic acid (2-oxo-cyclohexyl)-amide

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Reaction Steps

6.00 g 4-Methoxy-7-morpholin-4-yl-benzothiazole-2-carboxylic acid and 3.75 g 1,1′-carbonyl-diimidazole in 360 ml dimethylformamide were stirred at room temperature for 16 hours. 3.36 g 2-amino-cyclohexanone hydrochloride and 3.14 ml triethylamine were added and stirring was continued over night at room temperature. Water was added and the mixture was extracted with ethylacetate. Chromatography on silicagel with ethylacetate/hexane 1:1 to yielded 0.16 g (2%) 4-methoxy-7-morpholin-4-yl-benzothiazole-2-carboxylic acid (2-oxo-cyclohexyl)-amide as a yellow solid; M.p.: 195–197° C.; MS (ISP): m/e=390 (M+H+).

Provenance & Evidence