HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium trifluoroacetate → 4-methoxy-7-morpholin-4-yl-2-(4,5,6,7-tetrahydro-1H-benzoimidazol-2-yl)-benzothiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium trifluoroacetate | HCID 2724268 | — |
| Reactant | 4-Methoxy-7-morpholin-4-yl-benzothiazole-2-carboxylic acid (2-oxo-cyclohexyl)-amide | HCID 86595006 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-methoxy-7-morpholin-4-yl-2-(4,5,6,7-tetrahydro-1H-benzoimidazol-2-yl)-benzothiazole | HCID 11314705 | 42.1% |
Reaction Steps
A mixture of 0.10 g 4-methoxy-7-morpholin-4-yl-benzothiazole-2-carboxylic acid (2-oxo-cyclohexyl)-amide and 0.34 g ammonium triflouroacetate was melted at 165° C. for 50 minutes and, after cooling to room temperature, suspended in water. Extraction with dichloromethane and chromatography on silicagel with ethylacetate/hexane 6:4 gave 0.04 g (39%) 4-methoxy-7-morpholin-4-yl-2-(4,5,6,7-tetrahydro-1H-benzoimidazol-2-yl)-benzothiazole as light brown solid; MS (ISP): m/e=371 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07122545B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-6675db5f0e4c45d88956656b2ddf595a |
| Source note | uspto-grants-2006_10 |