Diisopropylethylamine → HCID 11282527, compound

Participants

Reaction Steps

To a suspension of 0.13 g 2-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-1,4,5,6,7,8-hexahydro-imidazo[4,5-d]azepine hydrochloride in 10 ml tetrahydrofurane were added at 0–4° C. 0.21 ml N-ethyldiisopropylamine and 0.037 g methoxyacetyl chloride. The mixture was refluxed for 17 hours, silicagel was added and the solvent was distilled off. The residue was transferred to a column prefilled with silicagel and was chromatographed with dichloromethane/methanol 96:4 to yield 0.126 g (91%) 2-methoxy-1-[2-(4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-4,5,7,8-tetrahydro-1H-imidazo[4,5-d]azepin-6-yl]-ethanone as yellow solid; MS (ISP): m/e=458 (M+H+).

Provenance & Evidence