4-(4-methoxy-3-nitro-phenyl)-3,6-dihydro-2H-pyran → 2-Methoxy-5-(tetrahydropyran-4-yl)-phenylamine

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Reaction Steps

1.3 g 4-(4-Methoxy-3-nitro-phenyl)-3,6-dihydro-2H-pyran (5.5 mmol) was dissolved in ethanol (100 ml) and treated with Pd/C 10% (0.065 g) under an atmosphere of hydrogen for 16 h. After filtration, evaporation and drying of the residue, 0.82 g of 2-methoxy-5-(tetrahydro-pyran-4-yl)-phenylamine (71%) were obtained as an off-white solid; M.p.: 102–103° C.

Provenance & Evidence