2,6-Dichloropyrazine → HCID 58717079, compound

HRID 1244386Notes

Reaction equation

HRID 1244386 reaction equation
[C@H:1]1([NH2:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[Cl:12][C:13]1[CH:18]=[N:17][CH:16]=[C:15](Cl)[N:14]=1>>[Cl:12][C:13]1[N:14]=[C:15]([NH:11][C@H:1]2[C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH2:4][CH2:3][CH2:2]2)[CH:16]=[N:17][CH:18]=1

Participants

3

Reactant 2

HCID 785042,6-DichloropyrazineHCID 70580721-Aminotetralin, (R)-

Product 1

HCID 58717079HCID 58717079, compoundYield 74%

Procedure

In a procedure analogous to Example 1, reaction of (1R)-1,2,3,4-tetrahydronaphthalen-1-amine (441 mg, 3.0 mmol) and 2,6-dichloropyrazine (0.4055 g, 2.72 mmol) furnished the product (521 mg, 74%).

Sources & evidence

ORD record
ord-e8a2830f33174273b3ce3bb13e679769
Source dataset
uspto-grants-2006_10
Patent number
US07122550B2

Reaction notes

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