2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol → HCID 136122428, compound

HRID 1244387Notes

Reaction equation

HRID 1244387 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][C@H:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH2:12][CH2:11][CH2:10]2)[CH:5]=[N:4][CH:3]=1.[CH3:19][O:20][C:21]1[CH:26]=[C:25](B2OC(C)(C)C(C)(C)O2)[CH:24]=[CH:23][C:22]=1[OH:36]>>[CH3:19][O:20][C:21]1[CH:26]=[C:25]([C:2]2[CH:3]=[N:4][CH:5]=[C:6]([NH:8][C@H:9]3[C:18]4[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=4)[CH2:12][CH2:11][CH2:10]3)[N:7]=2)[CH:24]=[CH:23][C:22]=1[OH:36]

Participants

3

Reactant 2

HCID 27346502-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenolHCID 58717079HCID 58717079, compound

Product 1

HCID 136122428HCID 136122428, compoundYield 47%

Procedure

In a procedure analogous to Example 2, reaction of 6-chloro-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]pyrazin-2-amine (139 mg, 0.536 mmol) and 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (147 mg, 0.59 mmol) furnished the product (87 mg, 47%).

Sources & evidence

ORD record
ord-12ee170c36b8451ea61216f232c055cc
Source dataset
uspto-grants-2006_10
Patent number
US07122550B2

Reaction notes

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