2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol → HCID 136122433, compound

HRID 1244388Notes

Reaction equation

HRID 1244388 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][C@H:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH2:11][CH2:10]2)[CH:5]=[N:4][CH:3]=1.[CH3:18][O:19][C:20]1[CH:25]=[C:24](B2OC(C)(C)C(C)(C)O2)[CH:23]=[CH:22][C:21]=1[OH:35]>>[C@H:9]1([NH:8][C:6]2[N:7]=[C:2]([C:24]3[CH:23]=[CH:22][C:21]([OH:35])=[C:20]([O:19][CH3:18])[CH:25]=3)[CH:3]=[N:4][CH:5]=2)[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 27346502-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenolHCID 52192100HCID 52192100, compound

Product 1

HCID 136122433HCID 136122433, compoundYield 70%

Procedure

In a procedure analogous to Example 2, reaction of 6-chloro-N-[(1R)-2,3-dihydro-1H-inden-1-yl]pyrazin-2-amine (136.8 mg, 0.56 mmol) and 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (153 mg, X0.61 mmol) furnished the product (130 mg, 70%).

Sources & evidence

ORD record
ord-d193b362e6a54bc89f0815225f63f989
Source dataset
uspto-grants-2006_10
Patent number
US07122550B2

Reaction notes

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