HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol → 2-Methoxy-4-(6-{[(1S)-1-phenylethyl]amino}pyrazin-2-yl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol | HCID 2734650 | — |
| Reactant | 6-Chloro-N-[(1S)-1-phenylethyl]pyrazin-2-amine | HCID 58717080 | — |
| Product | 2-Methoxy-4-(6-{[(1S)-1-phenylethyl]amino}pyrazin-2-yl)phenol | HCID 135421242 | 70% |
Reaction Steps
In a procedure analogous to Example 2, reaction of 6-chloro-N-[(1S)-1-phenylethyl]pyrazin-2-amine (717.3 mg, 3.07 mmol) and 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (845 mg, 3.38 mmol) furnished the product (689 mg, 70%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07122550B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-ba6657afadab44d9a113ec8092cafdd8 |
| Source note | uspto-grants-2006_10 |