2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol → HCID 135448175, compound

HRID 1244391Notes

Reaction equation

HRID 1244391 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][C@H:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:10][CH3:11])[CH:5]=[N:4][CH:3]=1.[CH3:18][O:19][C:20]1[CH:25]=[C:24](B2OC(C)(C)C(C)(C)O2)[CH:23]=[CH:22][C:21]=1[OH:35]>>[CH3:18][O:19][C:20]1[CH:25]=[C:24]([C:2]2[CH:3]=[N:4][CH:5]=[C:6]([NH:8][C@H:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH2:10][CH3:11])[N:7]=2)[CH:23]=[CH:22][C:21]=1[OH:35]

Participants

3

Reactant 2

HCID 27346502-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenolHCID 58717120HCID 58717120, compound

Product 1

HCID 135448175HCID 135448175, compoundYield 45.5%

Procedure

In a procedure analogous to Example 2, reaction of 6-chloro-N-[(1S)-1-phenylpropyl]pyrazin-2-amine (135 mg, 0.57 mmol) and 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (158 mg, 0.63 mmol) furnished the product (87 mg, 45%).

Sources & evidence

ORD record
ord-b45226632b4745e489528456fe3c0d3e
Source dataset
uspto-grants-2006_10
Patent number
US07122550B2

Reaction notes

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