2,6-Dichloropyrazine → HCID 58717109, compound

HRID 1244392Notes

Reaction equation

HRID 1244392 reaction equation
[NH2:1][C@H:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH2:3][OH:4].[Cl:11][C:12]1[CH:17]=[N:16][CH:15]=[C:14](Cl)[N:13]=1>>[Cl:11][C:12]1[N:13]=[C:14]([NH:1][C@H:2]([C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH2:3][OH:4])[CH:15]=[N:16][CH:17]=1

Participants

3

Reactant 2

HCID 785042,6-DichloropyrazineHCID 2724025(R)-beta-aminophenethyl alcohol

Product 1

HCID 58717109HCID 58717109, compoundYield 37.5%

Procedure

In a procedure analogous to Example 1, reaction of (2R)-2-amino-2-phenylethanol (420 mg, 3.1 mmol) and 2,6-dichloropyrazine (415 mg, 2.79 mmol) furnished the product (261 mg, 37%).

Sources & evidence

ORD record
ord-a8ceb0c9b5aa4181bf35e566b607370e
Source dataset
uspto-grants-2006_10
Patent number
US07122550B2

Reaction notes

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