HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol → 2-Methoxy-4-(6-{[(1S)-1-(4-methoxyphenyl)ethyl]amino}pyrazin-2-yl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol | HCID 2734650 | — |
| Reactant | 6-Chloro-N-[(1S)-1-(4-methoxyphenyl)ethyl]pyrazin-2-amine | HCID 58717083 | — |
| Product | 2-Methoxy-4-(6-{[(1S)-1-(4-methoxyphenyl)ethyl]amino}pyrazin-2-yl)phenol | HCID 136122439 | 35.4% |
Reaction Steps
In a procedure analogous to Example 2, reaction of 6-chloro-N-[(15)-1-(4-methoxyphenyl)ethyl]pyrazin-2-amine (149.4 mg, 0.57 mmol) and 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (156 mg, 0.62 mmol) furnished the product (71 mg, 35%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07122550B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-df9bac0a0ab54c74ab098f15904e6274 |
| Source note | uspto-grants-2006_10 |