2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol → HCID 135464141, compound

HRID 1244399Notes

Reaction equation

HRID 1244399 reaction equation
[CH2:1]([N:8]([CH3:16])[C:9]1[CH:14]=[N:13][CH:12]=[C:11](Cl)[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:17][O:18][C:19]1[CH:24]=[C:23](B2OC(C)(C)C(C)(C)O2)[CH:22]=[CH:21][C:20]=1[OH:34]>>[CH2:1]([N:8]([CH3:16])[C:9]1[N:10]=[C:11]([C:23]2[CH:22]=[CH:21][C:20]([OH:34])=[C:19]([O:18][CH3:17])[CH:24]=2)[CH:12]=[N:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27346502-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenolHCID 21919354HCID 21919354, compound

Product 1

HCID 135464141HCID 135464141, compoundYield 51%

Procedure

In a procedure analogous to Example 22, reaction of N-benzyl-6-chloro-N-methylpyrazin-2-amine and 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol furnished the product (51%).

Sources & evidence

ORD record
ord-21ac2dd77a84481cb97769702b422f8e
Source dataset
uspto-grants-2006_10
Patent number
US07122550B2

Reaction notes

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