1,2,3,4-Tetrahydroisoquinoline → 2-(6-Chloro-2-pyrazinyl)-1,2,3,4-tetrahydroisoquinoline

HRID 1244400Notes

Reaction equation

HRID 1244400 reaction equation
[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][NH:2]1.[Cl:11][C:12]1[CH:17]=[N:16][CH:15]=[C:14](Cl)[N:13]=1>>[Cl:11][C:12]1[N:13]=[C:14]([N:2]2[CH2:3][CH2:4][C:5]3[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=3)[CH2:1]2)[CH:15]=[N:16][CH:17]=1

Participants

3

Reactant 2

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 785042,6-Dichloropyrazine

Product 1

HCID 100832472-(6-Chloro-2-pyrazinyl)-1,2,3,4-tetrahydroisoquinolineYield 95%

Procedure

In a procedure analogous to Example 21, reaction of tetrahydroisoquinoline and 2,6-dichloropyrazine furnished the product (95%).

Sources & evidence

ORD record
ord-434e9b5f412d4612a43f9c52b8cc7177
Source dataset
uspto-grants-2006_10
Patent number
US07122550B2

Reaction notes

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