2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol → HCID 135856786, compound

HRID 1244401Notes

Reaction equation

HRID 1244401 reaction equation
Cl[C:2]1[N:7]=[C:6]([N:8]2[CH2:17][CH2:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[CH2:9]2)[CH:5]=[N:4][CH:3]=1.[CH3:18][O:19][C:20]1[CH:25]=[C:24](B2OC(C)(C)C(C)(C)O2)[CH:23]=[CH:22][C:21]=1[OH:35]>>[CH2:9]1[C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH2:16][CH2:17][N:8]1[C:6]1[N:7]=[C:2]([C:24]2[CH:23]=[CH:22][C:21]([OH:35])=[C:20]([O:19][CH3:18])[CH:25]=2)[CH:3]=[N:4][CH:5]=1

Participants

3

Reactant 2

HCID 27346502-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenolHCID 100832472-(6-Chloro-2-pyrazinyl)-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 135856786HCID 135856786, compoundYield 44%

Procedure

In a procedure analogous to Example 22, reaction of 2-(6-chloropyrazin-2-yl)-1,2,3,4-tetrahydroisoquinoline and 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol furnished the product (44%).

Sources & evidence

ORD record
ord-4a305cd5412648f1acd6c1d44364ba7b
Source dataset
uspto-grants-2006_10
Patent number
US07122550B2

Reaction notes

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