Benzenemethanamine, 3,4-dichloro- → 6-Chloro-N-(3,4-dichlorobenzyl)pyrazin-2-amine

HRID 1244402Notes

Reaction equation

HRID 1244402 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[Cl:10])[CH2:5][NH2:6].[Cl:11][C:12]1[CH:17]=[N:16][CH:15]=[C:14](Cl)[N:13]=1>>[Cl:11][C:12]1[N:13]=[C:14]([NH:6][CH2:5][C:4]2[CH:7]=[CH:8][C:9]([Cl:10])=[C:2]([Cl:1])[CH:3]=2)[CH:15]=[N:16][CH:17]=1

Participants

3

Reactant 2

HCID 1608Benzenemethanamine, 3,4-dichloro-HCID 785042,6-Dichloropyrazine

Product 1

HCID 219193476-Chloro-N-(3,4-dichlorobenzyl)pyrazin-2-amineYield 89%

Procedure

In a procedure analogous to Example 21, reaction of 3,4-dichlorobenzylamine and 2,6-dichloropyrazine furnished the product (89%).

Sources & evidence

ORD record
ord-4a4ddf00b3484eb5b6e2636250f5fd6d
Source dataset
uspto-grants-2006_10
Patent number
US07122550B2

Reaction notes

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