2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol → HCID 135856784, compound

HRID 1244405Notes

Reaction equation

HRID 1244405 reaction equation
Cl[C:2]1[N:7]=[C:6]([NH:8][CH2:9][C:10]2[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[C:12]([O:18][CH3:19])[CH:11]=2)[CH:5]=[N:4][CH:3]=1.[CH3:20][O:21][C:22]1[CH:27]=[C:26](B2OC(C)(C)C(C)(C)O2)[CH:25]=[CH:24][C:23]=1[OH:37]>>[CH3:19][O:18][C:12]1[CH:11]=[C:10]([CH:15]=[C:14]([O:16][CH3:17])[CH:13]=1)[CH2:9][NH:8][C:6]1[N:7]=[C:2]([C:26]2[CH:25]=[CH:24][C:23]([OH:37])=[C:22]([O:21][CH3:20])[CH:27]=2)[CH:3]=[N:4][CH:5]=1

Participants

3

Reactant 2

HCID 27346502-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenolHCID 21919341HCID 21919341, compound

Product 1

HCID 135856784HCID 135856784, compoundYield 88%

Procedure

In a procedure analogous to Example 22, reaction of 6-chloro-N-(3,5-dimethoxybenzyl)pyrazin-2-amine and 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol furnished the product (88%).

Sources & evidence

ORD record
ord-52ead686be904f8c887ff419bc52777b
Source dataset
uspto-grants-2006_10
Patent number
US07122550B2

Reaction notes

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