(4-Nitrophenyl)acetic acid → Benzeneacetyl chloride, 4-nitro-

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Reaction Steps

3.75 ml (7.5 mmoles) of a 2 M solution of oxalyl chloride in dichloromethane is added at 20° C. to a solution of 0.9 g (5 mmoles) of 4-nitrophenylacetic acid in a mixture composed of 10 ml of dichloromethane and 0.5 ml of DMF. After agitation for 30 minutes, the solution is concentrated under vacuum. The yellow oil obtained is used without additional purification in the following stage.

Provenance & Evidence