(4-Methoxyphenyl)hydrazine → HCID 21919803, compound

Participants

Reaction Steps

Condensation of 4-methoxyphenylhydrazine with 4-[2,3-dioxo-4-(2,2,2-trifluoro-acetyl)-piperidin-1-yl]-benzonitrile afforded the desired intermediate 4-[1-(4-methoxy-phenyl)-7-oxo-3-trifluoromethyl-1,4,5,7-tetrahydro-pyrazolo[3,4-c]pyridin-6-yl]-benzonitrile. This intermediate was dissolved in anhydrous methanol and HCl gas was bubbled through for 15 min. The reaction mixture was stirred at room temperature for 18 h and concentrated. The residue was re-dissolved in methanol and 2 equivalents of N-methyl-ethylenediamine were added. The reaction mixture was stirred at room temperature for 18 h and concentrated. Pure product was obtained via reverse phase HPLC. ESI mass spectrum 470 (M+H)+.

Provenance & Evidence