HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → (RS)-1-[4-(4-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid methylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | HCID 68614531 | HCID 68614531 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (RS)-1-[4-(4-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid methylamide | HCID 10020246 | — |
Reaction Steps
In an analogous manner to that described in Example 1e), the aminolysis of the (RS)-1-[4-(4-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid methyl ester with methylamine in a sealed tube at 80° C. in ethanol during 18 h yields the (RS)-1-[4-(4-fluoro-benzyloxy)-phenyl]-5-oxo-pyrrolidine-3-carboxylic acid methylamide as a white powder; MS: m/e=343 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07122562B2 |
| Source dataset | uspto-grants-2006_10 |
| ORD ID | ord-9a6f3429a096462fa96a005a4d08e0a8 |
| Source note | uspto-grants-2006_10 |